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Hide Pathway Description Glutathione Synthetase Deficiency Homo sapiens Disease Pathway Created: 2013-08-01 Last Updated: 2026-05-21 Glutathione Synthetase Deficiency (5-Oxoprolinuria

EGCG can follow the mechanisms by which it can produce various effects including the upregulation of Bcl-2 associated X protein (Bax), a pro-apoptosis protein, the activation of caspases-3, -7 and -9, downregulation of proteins that inhibit apoptosis, or cell survival-promoting proteins (Bcl-2, D1 and cyclin-dependent kinase 2 (cdk2), and through the induction of tumor-suppressor proteins (p16INK4a, p21WAF1/CIP1, and p2KP1)

Furthermore, there is emerging evidence for the intergenerational effects of maternal B-vitamin status during pregnancy on the offspring development (Reference Finkelstein, Fothergill and Venkatramanan89,Reference McNulty, Rollins and Cassidy96,Reference Caffrey, McNulty and Rollins97)